GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | AMT | chr3:49454212-49460012:- | 0.13 | 4.33 | 1.65E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.97 | 7.69E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | NCKIPSD | chr3:48711280-48723334:- | 0.16 | 4.02 | 6.3E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | P4HTM | chr3:49027341-49044579:+ | 0.11 | 4.59 | 4.93E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | TREX1 | chr3:48501186-48509043:+ | -0.11 | -3.55 | 0.000398 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11720542 | chr3:49357427 | WDR6 | chr3:49044637-49053386:+ | -0.13 | -3.98 | 7.36E-5 | Menarche (age at onset) |
| BRCA | cis | rs3772130 | 1 | rs11721318 | chr3:121429485 | IQCB1 | chr3:121488610-121553926:- | 0.27 | 7.08 | 2.54E-12 | Cognitive performance |
| BRCA | cis | rs3772130 | 1 | rs11721318 | chr3:121429485 | SLC15A2 | chr3:121613171-121663034:+ | -0.13 | -3.86 | 0.00012 | Cognitive performance |
| BRCA | cis | rs1853207 | 1 | rs117215113 | chr10:96406092 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.4 | 8.04E-8 | Blood metabolite levels |
| BRCA | cis | rs11723261 | 1 | rs11722197 | chr4:281707 | ZNF718 | chr4:53272-156488:+ | 0.34 | 7.27 | 6.78E-13 | Immune response to smallpox vaccine (IL-6) |
| BRCA | cis | rs76419734 | 1 | rs11722225 | chr4:106766430 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.5 | 0.000478 | Post bronchodilator FEV1 |
| BRCA | cis | rs11723261 | 1 | rs11722521 | chr4:276765 | ZNF718 | chr4:53272-156488:+ | 0.34 | 7.29 | 5.93E-13 | Immune response to smallpox vaccine (IL-6) |
| BRCA | cis | rs3774959 | 1 | rs11723120 | chr4:103502551 | MANBA | chr4:103552644-103682151:- | 0.16 | 3.98 | 7.22E-5 | Ulcerative colitis |
| BRCA | cis | rs11723261 | 1 | rs11723261 | chr4:282499 | ZNF718 | chr4:53272-156488:+ | 0.34 | 7.27 | 6.78E-13 | Immune response to smallpox vaccine (IL-6) |
| BRCA | cis | rs11723261 | 1 | rs11723615 | chr4:276983 | ZNF718 | chr4:53272-156488:+ | 0.35 | 7.43 | 2.19E-13 | Immune response to smallpox vaccine (IL-6) |